I've found an interisting alternative to Photopshop and the Gimp, you'd never guess, what it's called. Gimpshop. No, I'm not kidding. Someone tried to change the quite "unusual" GUI of the Gimp into a Photoshop alike one. Well it does'nt fix the terrible CMYK mode of the Gimp, so it's still not the first choice, when it comes to create printed media, but it's really worth the look, if you're into web- game etc-design.
Have a look at http://gimpshopdotnet.blogspot.com/
and have fun.
In comparison to the quite unstable Pixel32, the chaotic Gimp gui and the very expensive Photoshop, Gimpshop really makes some points. (No I'm not involved in the creation of this tool in any way).
Maybe our beloved moderator could put this onto the list on the first site of this thread....