I've done that a bunch of times; when you're on a computer you haven't used before, you just have to tell WME where all the different tools are.
After that, though, it's really easy. Only trouble I ever had with it was when one computer wouldn't recognize the script editor to open scripts. But that was one computer.
Heck, I got it to run off a USB drive on a Mac once using CrossOver... didn't work very well, but enough to let people play my test version on Macs.