Well, the topic was not aiming just on the item picking animations. I was asking how to create whole in-game animation when one or more characters are moving and picking objects and maybe fighting, shaking hands, combining objects, etc...
I think that the best way would be to get animation software where you can import background picture and then put on characters and objects and create animation. And we also have prerendered 3D characters. I know how to animate 3D character but scale and position on 2D background and connecting it to the 2D objects that he is picking up is mistery here.
and Kaddafi, your English is just fine
and continue with developing such great engine!!! 
.
