No, but you have the problem that most ppl have high res widescreen lcd displays. When you play fullscreen, you will have black bars left and right, which does not look good in my opinioin. And the lower the resolution of your game is, the "blurrier" (dont know the word) it looks when playing in fullscreen mode. So 1280x800 (or 1024x768 if you want) is the best choice today imo.